Clinical evidence for PWs are established and demonstrate a significant mortality benefit. The reason this life saving technology is not used more often is that current products often cannot be advanced past arterial blockages. Sensor performance is also poor. CorMetrics’ PW addresses shortcomings current products providing physicians the confidence needed to pull the product off the shelf for all 3.3 million US patients treated annually. CorMetrics’ novel Pressure Wire (PW) for cardiology combines the world’s smallest MEMs piezo-resistive sensor, a newly designed guide wire platform and novel circuitry offering breakthrough performance. Our MEMs sensor establishes new benchmarks for pressure sensing stability, response and accuracy. The guidewire design has been optimized for the sensor’s tiny size, eliminating a hollow tube used in every other PW. The tube, used to route wires, necessitates structural compromises undermining the device’s ability to be delivered to the target site.